Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells.

Marina CondeSusanne MichenRalf WiedemuthBarbara KlinkEvelin SchröckGabriele SchackertAchim Temme

Published in: BMC cancer (2017)

Our data suggest that increased Survivin levels promote adaptive evolution of tumors through combining induction of genetic heterogeneity with inhibition of apoptosis.

Keyphrases

oxidative stress
copy number
endoplasmic reticulum stress
single cell
cell death
electronic health record
big data
gene expression
deep learning