Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy.

Adam C MidgleyYongzhen WeiDashuai ZhuFangli GaoHongyu YanAnila KhaliqueWenya LuoHuan JiangXiangsheng LiuJiasen GuoChuangnian ZhangGuowei FengKai WangXueyuan BaiWen NingChao YangQiang ZhaoDeling Kong

Published in: Journal of the American Society of Nephrology : JASN (2020)

Nanoparticle delivery of HGF/NK1 conveyed potent antifibrotic and proregenerative effects. Overall, this research provided the proof of concept on which to base future investigations for enhanced targeting and transfection of therapeutic genes to kidney tissues, and an avenue toward treatment of CKD.

Keyphrases

chronic kidney disease
genome wide
cancer therapy
genome wide identification
drug delivery
pulmonary fibrosis
gene expression
copy number
current status
stem cells
transcription factor
mesenchymal stem cells
cell therapy
nk cells
replacement therapy
smoking cessation