PI3Kδ/γ inhibitor BR101801 extrinsically potentiates effector CD8 + T cell-dependent antitumor immunity and abscopal effect after local irradiation.

Yi Na Yoon Eunju Lee Young-Ju KwonJeong-An GimTae-Jin Kim Jae Sung Kim

Published in: Journal for immunotherapy of cancer (2022)

Our data suggest the first evidence that PI3Kδ/γ inhibition combined with irradiation promotes systemic antitumor immunity against solid tumors, providing the preclinical result of the potential use of PI3Kδ/γ inhibitor as an immune-regulatory radiosensitizer.

Keyphrases

electronic health record
transcription factor
dendritic cells
regulatory t cells
radiation induced
cell therapy
immune response
mesenchymal stem cells
climate change
drug induced
artificial intelligence