Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice-Brief Report.
Lauren A BiwerJoshua J ManNicholas D CamardaBrigett V CarvajalS Ananth KarumanchiIris Z JaffePublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
In atherogenic LDLR-KO mice, exposure to sFlt1-induced preeclampsia during pregnancy increases future atherosclerotic plaque inflammation, supporting the concept that preeclampsia directly exacerbates atherosclerotic inflammation independent of preexisting risk factors. This mechanism may contribute to ischemic vascular disease in women after preeclampsia pregnancy.
Keyphrases
- pregnancy outcomes
- early onset
- oxidative stress
- risk factors
- pregnant women
- coronary artery disease
- diabetic rats
- polycystic ovary syndrome
- ischemia reperfusion injury
- high glucose
- type diabetes
- low density lipoprotein
- current status
- preterm birth
- endothelial cells
- blood brain barrier
- skeletal muscle
- brain injury
- cerebral ischemia