Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma.
Yang LiuYoshifumi BabaTakatsugu IshimotoHiroyasu TsutsukiTianli ZhangDaichi NomotoKazuo OkadomeKensuke YamamuraKazuto HaradaKojiro EtoYukiharu HiyoshiMasaaki IwatsukiYohei NagaiShiro IwagamiYuji MiyamotoNaoya YoshidaYoshihiro KomoharaMasaki OhmurayaXiaoming WangJaffer A AjaniTomohiro SawaHideo BabaPublished in: British journal of cancer (2020)
F. nucleatum confers chemoresistance to ESCC cells by modulating autophagy. These findings suggest that targeting F. nucleatum, during chemotherapy, could result in variable therapeutic outcomes for ESCC patients.
Keyphrases
- signaling pathway
- squamous cell carcinoma
- induced apoptosis
- cell death
- end stage renal disease
- endoplasmic reticulum stress
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cell cycle arrest
- locally advanced
- peritoneal dialysis
- prognostic factors
- metabolic syndrome
- adipose tissue
- drug delivery
- cancer therapy
- lymph node metastasis
- radiation therapy
- cell proliferation
- patient reported outcomes