[⁸⁹Zr]Zr-PSMA-617 PET/CT in biochemical recurrence of prostate cancer: first clinical experience from a pilot study including biodistribution and dose estimates.

[⁸⁹Zr]Zr-PSMA-617 PET/CT imaging is a promising new diagnostic tool with acceptable radiation exposure for patients with prostate cancer especially when [⁶⁸Ga]Ga-PSMA-11 PET/CT imaging fails detecting recurrent disease. The long half-life of ⁸⁹Zr enables late time point imaging (up to 72 h in our study) with increased tracer uptake in tumor lesions and higher tumor-to-background ratios allowing identification of lesions non-visible on [⁶⁸Ga]Ga-PSMA-11 PET/CT imaging.