Improving Granulosa Cell Function in Premature Ovarian Failure with Umbilical Cord Mesenchymal Stromal Cell Exosome-Derived hsa_circ_0002021.
Ge YangBo ZhangMei XuMingJun WuJie LinZiYu LuoYueHua ChenQin HuGuoPing HuangHaiYan HuPublished in: Tissue engineering and regenerative medicine (2024)
This study confirms that hsa_circ_0002021, when delivered through HUMSCs-Exo, can significantly mitigate GC senescence and restore ovarian function in POF models. These findings provide new insights into the molecular mechanisms of POF and highlight the therapeutic potential of circRNA-enriched exosomes in treating ovarian aging and dysfunction.