Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Yinghong WangDiana H WiesnoskiBeth A HelminkVancheswaran GopalakrishnanKati ChoiHebert L DuPontZhi-Dong JiangHamzah Abu-SbeihChristopher A SanchezChia-Chi ChangEdwin R ParraAlejandro Francisco-CruzGottumukkala S RajuJohn R StroehleinMatthew T CampbellJianjun GaoSumit K SubudhiDipen M MaruJorge M BlandoAlexander J LazarJames P AllisonPadmanee SharmaMichael T TetzlaffJennifer A WargoRobert R JenqPublished in: Nature medicine (2018)
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.