Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.
Prokopios P ArgyrisJordan NaumannMatthew C JarvisPeter E WilkinsonDan P HoMohammed N IslamIndraneel BhattacharyyaRajaram GopalakrishnanFaqian LiIoannis G KoutlasAlessio GiubellinoReuben S HarrisPublished in: Histopathology (2022)
The above data strongly indicate a possible role for the mutagenic enzyme A3B in head/neck melanomagenesis, but not benign melanocytic neoplasms.