The application of targeted RNA sequencing for the analysis of fusion genes, gene mutations, IKZF1 intragenic deletion, and CRLF2 overexpression in acute lymphoblastic leukemia.
Zhenyu ZhangYu JingBin ChenHong ZhangTuo LiuShuran DongLei ZhangXiaoyan YanShaobin YangLong ChenYani LinKun RuPublished in: International journal of laboratory hematology (2024)
The utilization of RNA-seq enables the identification of clinically significant genetic abnormalities that may go undetected through conventional detection methods. Its robust analytical performance might bring great application value for clinical diagnosis, prognosis, and therapy in ALL.
Keyphrases
- rna seq
- single cell
- acute lymphoblastic leukemia
- genome wide
- bioinformatics analysis
- allogeneic hematopoietic stem cell transplantation
- cell proliferation
- cancer therapy
- transcription factor
- loop mediated isothermal amplification
- stem cells
- label free
- real time pcr
- genome wide identification
- smoking cessation
- sensitive detection