Proteoglycans orchestrate remodeling of prostatic cytoarchitecture after androgenic blockade in old gerbils.
Silvana G P CamposBianca F GonçalvesThalles Fernando Rocha RuizEllen Cristina R LeonelDaniele L RibeiroLuiz Roberto Falleiros JuniorRejane Maira GóesSebastião Roberto TabogaPublished in: The Prostate (2022)
In this study, in particular, the decrease in chondroitin sulfate after the longer period might be understood as a prostatic response to androgenic deprivation, while the high frequency and permanence of perlecan led to the assumption that its modulation could be androgen-independent. Length and form alterations in proteoglycans as well as associations among them and with the basement membrane were dynamic events in the prostate microenvironment.