Effects of subthalamic nucleus stimulation and levodopa on decision-making in Parkinson's disease.

Cyril Atkinson-ClementÉmilie CavazziniAlexandre ZénonTatiana WitjasFrédérique FluchèreJean-Philippe AzulayChristelle BaunezAlexandre Eusebio

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

Our study shows that l-dopa administration does not fully restore cost-benefit decision-making processes, whereas STN-DBS fully normalizes patients' behaviors. These findings suggest that dopamine is partly involved in cost-benefit valuation, and that STN-DBS can have a beneficial effect on motivated behaviors in PD and may improve certain forms of impulsive behaviors. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

deep brain stimulation
parkinson disease
end stage renal disease
decision making
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
uric acid
patient reported outcomes