Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes.

Pang YaoAndri IonaAlfred PozarickijSaredo SaidNeil WrightKuang LinIona MillwoodHannah FryChristiana KartsonakiMohsen MazidiYiping ChenFiona BraggBowen LiuLing YangJunxi LiuDaniel AveryDan SchmidtDianjianyi SunPei PeiJun Lv Canqing YuMichael HillDerrick A BennettRobin WaltersLiming LiRobert J Clarke Huaidong Du Zhengming Chennull null

Published in: Diabetes care (2024)

Proteomic analyses in Chinese adults identified novel associations of multiple proteins with T2D with strong genetic evidence supporting their causal relevance and potential as novel drug targets for prevention and treatment of T2D.

Keyphrases

type diabetes
label free
cardiovascular disease
adverse drug
genome wide
insulin resistance
drug induced
copy number
risk assessment
gene expression
human health
skeletal muscle
combination therapy
metabolic syndrome
weight loss
replacement therapy
electronic health record
smoking cessation