High Mobility Group Box 1 as an Autocrine Chemoattractant for Oligodendrocyte Lineage Cells in White Matter Stroke.
Jun Young ChoiXuelian JinHanki KimSeungyon KohHyo Jin ChoByung Gon KimPublished in: Stroke (2022)
HMGB1, through the TLR2-ERK1/2-FAK axis, functions as an autocrine chemoattractant to promote OPC migration, which is an initial and indispensable step in remyelination. Thus, a novel treatment strategy for white matter stroke based on the HMGB1-TLR2 axis in the oligodendrocyte lineage could be feasible.
Keyphrases
- white matter
- atrial fibrillation
- toll like receptor
- multiple sclerosis
- inflammatory response
- induced apoptosis
- immune response
- signaling pathway
- single cell
- cell cycle arrest
- pi k akt
- nuclear factor
- cell proliferation
- cerebral ischemia
- cell fate
- combination therapy
- endoplasmic reticulum stress
- oxidative stress
- cell death