Proinflammatory role of basophils in oxazolone-induced chronic intestinal inflammation.

Kenichi InabaMasaaki HigashiyamaChikako WatanabeAkira TomiokaSuguru ItoRina TanemotoAkinori MizoguchiShin NishiiAkinori WadaNao SugiharaYoshinori HanawaKazuki HoriuchiYoshihiro AkitaYoshikiyo OkadaChie KuriharaKazuyuki NarimatsuShunsuke KomotoKengo TomitaHajime KarasuyamaTakahiro SatohRyota Hokari

Published in: Journal of gastroenterology and hepatology (2022)

Basophil infiltration correlated with endoscopic, clinical, and pathological scores in human UC independently of eosinophil infiltration, and depletion of basophils ameliorated mucosal inflammation in murine OXA-induced colitis, collectively suggesting that basophils exert a proinflammatory role in chronic intestinal inflammation such as UC.

Keyphrases

oxidative stress
diabetic rats
drug induced
ultrasound guided
acinetobacter baumannii
pseudomonas aeruginosa
cystic fibrosis
ulcerative colitis
stress induced