The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1.

Lingxiao ZhangLin JiangLing ZengZhaohui JinXuanjia DongYuhan ZhangLitian ChenYijun ShuYingbin LiuYing Huang

Published in: Journal of translational medicine (2023)

Our findings discovered a novel oncogenic function of NF1 by directly interacting with YAP1 protein and stabilizing YAP1 to protect it from proteasome degradation in NOZ cells. NF1 may serve as a potential therapeutic target in GBC.

Keyphrases

signaling pathway
lps induced
pi k akt
induced apoptosis
nuclear factor
cell cycle arrest
oxidative stress
transcription factor
inflammatory response
cell death
binding protein
endoplasmic reticulum stress
small molecule
young adults
human health
squamous cell