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Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma.

Lindsey E JonesStephanie HilzMatthew R GrimmerTali MazorChloé NajacJoydeep MukherjeeAndrew McKinneyTracy ChowRussell O PieperSabrina M RonenSusan M ChangJoanna J PhillipsJoseph F Costello
Published in: Neuro-oncology advances (2020)
These PDCs, scPDCs, and PDX are unique and versatile community resources that model the heterogeneous clonal origins and functions of recurrent IDH1-mutant LGGs. The integrated phylogenies advance our knowledge of the complex evolution and immense mutational load of IDH1-mutant HM glioma.
Keyphrases
  • wild type
  • low grade
  • healthcare
  • mental health