Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma.
Lindsey E JonesStephanie HilzMatthew R GrimmerTali MazorChloé NajacJoydeep MukherjeeAndrew McKinneyTracy ChowRussell O PieperSabrina M RonenSusan M ChangJoanna J PhillipsJoseph F CostelloPublished in: Neuro-oncology advances (2020)
These PDCs, scPDCs, and PDX are unique and versatile community resources that model the heterogeneous clonal origins and functions of recurrent IDH1-mutant LGGs. The integrated phylogenies advance our knowledge of the complex evolution and immense mutational load of IDH1-mutant HM glioma.