Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients.
Tingjie GuoReinier M van HestLaura B ZwepLuca F RoggeveenLucas M FleurenRob J BosmanPeter H J van der VoortArmand R J GirbesRon A A MathotPaul W G ElbersJohan G C van HasseltPublished in: Pharmaceutical research (2020)
The proposed adaptive MAP method outperforms standard MAP in predictive performance and may be considered for improvement of model-based dose optimization. The inclusion of historical data beyond either one day (standard MAP and weighted MAP) or two days (adaptive MAP) reduces predictive performance.