Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis.
Minjung KimNgoc T VuXue WangGamze B BulutMin-Hsuan WangCora Uram-TuculescuRaghavendra PillappaSungjune KimCharles E ChalfantPublished in: Molecular cancer research : MCR (2022)
Our findings show that C9b can directly activate NF-κB pathway in vivo to modulate lung inflammation, immune cell influx, and peripheral immune responses, which demonstrates that C9b is key factor in driving cell transformation and lung tumorigenesis.