Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results.

Matthew J WieduwiltNela PawlowskaScott ThomasRebecca OlinAaron C LoganLloyd E DamonThomas MartinMcNancy KangPeter H SayreWanda BoyerKarin M L GaenslerKirsten AndersonPamela N MunsterCharalambos Andreadis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Panobinostat with "7+3" for older patients with AML was well tolerated. Panobinostat 50 mg on days 1, 3, 5, and 8 starting 2 days prior to "7+3" is recommended for future studies. Panobinostat-induced increases in histone acetylation in PBMCs predicted CR/CRi.

Keyphrases

histone deacetylase
acute myeloid leukemia
community dwelling
physical activity
allogeneic hematopoietic stem cell transplantation
dna methylation
high glucose
diabetic rats
gene expression
current status
squamous cell carcinoma
locally advanced
oxidative stress
case control
drug induced
endothelial cells