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Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts.

Paul M BarrAlessandra TedeschiWilliam G WierdaJohn N AllanPaolo GhiaDaniele VallisaRyan JacobsSusan M O'BrienAndrew P GriggPatricia WalkerCathy ZhouJoi NinomotoGabriel KrigsfeldConstantine S Tam
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Three cycles of ibrutinib lead-in before venetoclax initiation provides effective tumor debulking, decreases the TLS risk category and reduces the need for hospitalization for intensive monitoring for TLS.
Keyphrases
  • chronic lymphocytic leukemia
  • neoadjuvant chemotherapy
  • radiation therapy
  • locally advanced
  • rectal cancer