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Characterizing the host response to rhPDGF-BB in a rat spinal arthrodesis model.

Jonathan T YamaguchiJoseph A WeinerSilvia MinardiAllison C GreeneDavid J EllenbogenMitchell J HallmanVivek P ShahKevin M WeiszSoyeon JeongTejas NandurkarChawon YunWellington K HsuErin L Hsu
Published in: JOR spine (2021)
rhPDGF-BB delivered with a β-TCP/Col matrix exerts no exaggerated systemic or local host inflammatory response when compared to iliac crest syngeneic allograft bone or the control carrier. rhPDGF-BB mixed with a β-TCP/Col matrix could be a viable and safe biologic alternative to syngeneic allograft in spine fusion. Further studies need to be performed to evaluate efficacy in this setting.
Keyphrases
  • growth factor
  • inflammatory response
  • recombinant human
  • rheumatoid arthritis
  • spinal cord
  • kidney transplantation
  • lipopolysaccharide induced
  • lps induced
  • toll like receptor
  • spinal cord injury
  • body composition