Modulation of hippocampal protein expression by a brain penetrant biologic TNF-α inhibitor in the 3xTg Alzheimer's disease mice.

Nataraj JagadeesanG Chuli RoulesDevaraj V ChandrashekarJoshua YangSanjana KolluruRachita K Sumbria

Published in: Journal of translational medicine (2024)

Overall, despite the low visual Aβ load in the 11-month-old female 3xTg-AD mice, our results highlight region-specific AD-relevant DEP in the hippocampus of these mice. Chronic TfRMAb-TNFR dosing modulated several DEP involved in AD pathology and showed a largely microglia-centric mechanism of action in the 3xTg-AD mice.

Keyphrases

high fat diet induced
rheumatoid arthritis
wild type
type diabetes
metabolic syndrome
adipose tissue
cognitive decline
mild cognitive impairment