A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer.

Kristin A Altwegg Suryavathi Viswanadhapalli Monica Mann Dimple Chakravarty Samaya Krishnan Zexuan Liu Junhao Liu Uday P Pratap Behnam Ebrahimi John R Sanchez Xiaonan Li Shihong Ma Ben Ho Park Bindu Santhamma Yidong Chen Zhao Lai Ganesh V Raj Yaxia Yuan Daohong Zhou Gangadhara R Sareddy Rajeshwar R Tekmal Stanton F McHardy Tim Hui-Ming Huang Manjeet K Rao Hariprasad Vankayalapati Ratna K Vadlamudi

Published in: Cancer research (2022)

Development of a novel inhibitor of oncogenic PELP1 provides potential therapeutic avenues for treating therapy-resistant, advanced ER+ breast cancer.

Keyphrases

endoplasmic reticulum
estrogen receptor
breast cancer cells
breast cancer risk
bone marrow