Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children With Acute Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome With Similar Levels of Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 Shedding.
Nadine Peart AkindeleTheodore KouoAndrew H KarabaOren GordonKatherine Z J FenstermacherJeanette BeaudryJessica H RubensChristine C AtikWeiqiang ZhouHongkai JiXueting TaoDhananjay VaidyaHeba MostafaPatrizio CaturegliPaul W BlairLauren SauerAndrea L CoxDeborah PersaudPublished in: The Journal of infectious diseases (2021)
The distinct pattern of heightened cytokine/chemokine dysregulation observed with MIS-C, compared with acute COVID-19, occurs across the pediatric age spectrum and with similar levels of nasopharyngeal SARS-CoV-2 RNA.