Modulation of DNA Methylation/Demethylation Reactions Induced by Nutraceuticals and Pollutants of Exposome Can Promote a C > T Mutation in the Breast Cancer Predisposing Gene PALB2 .
Florestan CourantGwenola Bougras-CartronCaroline AbadieJean-Sébastien FrenelPierre-François CartronPublished in: Epigenomes (2022)
Our study provides a proof of concept supporting the idea that exposomes can generate genetic mutation by affecting DNA methylation/demethylation.