Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles.

Jingyi ZhangYing LiChaofeng ZhangXiao-Na Wang Jun-Biao Chang

Published in: Organic letters (2021)

A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.

Keyphrases

metal organic framework
drug delivery
molecular dynamics
high throughput
cancer therapy
quantum dots
reduced graphene oxide
highly efficient
low cost
electron transfer
gold nanoparticles