Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling.

Ka-Young RyuHyun-Ju LeeHanwoong WooRi-Jin KangKyung-Min HanHyunHee ParkSang Min LeeJu-Young LeeYoo Joo JeongHyun-Wook NamYoungpyo NamHyang-Sook Hoe

Published in: Journal of neuroinflammation (2019)

Our results suggest that dasatinib modulates LPS-induced microglial and astrocytic activation, proinflammatory cytokine levels, and neutrophil rolling in the brain.

Keyphrases

lps induced
inflammatory response
signaling pathway
cell proliferation
chronic myeloid leukemia
resting state
white matter
lipopolysaccharide induced
functional connectivity
cerebral ischemia
brain injury
spinal cord
subarachnoid hemorrhage