Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial): a randomised trial and pharmacological study in caesarean section births.

Haleema Shakur-StillIan RobertsStanislas Grassin-DelyleRizwana ChaudhriAmber GeerMonica ArribasElodie LamyRaoul MansukhaniMwansa Ketty LubeyaKiran JavaidAasia KayaniNaila IsrarSyeda Batool MazharSaïk UrienNaïm BouazzaFrantz FoissacDanielle ProwseLaura CarringtonCollette BarrowJulio Gil OnandiaEni Balogun

Published in: BJOG : an international journal of obstetrics and gynaecology (2023)

Both IM and oral TXA are well tolerated. Oral TXA took about 1 hour to reach minimum therapeutic concentrations and would not be suitable for emergency treatment. Intramuscular TXA inhibits fibrinolysis within 10 minutes and may be a suitable alternative to IV.

Keyphrases

study protocol
emergency department
healthcare
public health
pregnant women
combination therapy
case report
atrial fibrillation
gestational age