Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro.

Aneta LedererovaLenka DostalovaVeronika KozlovaHelena PeschelovaAdriana LadungovaMartin CulenTomas LojaJan VernerSarka PospisilovaMichal Smida Veronika Mančíková

Published in: Journal for immunotherapy of cancer (2022)

Epigenetically driven antigen escape could represent a novel, yet at least partially reversible, means of CD19 loss to CART-19 in B-cell tumors.

Keyphrases

dna methylation
gene expression
nk cells
transcription factor