Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine.

Sarah A SchoenrockPadam KumarAlexander Gómez-APrice E DicksonSam-Moon KimLauren BaileySofia NeiraKyle D RikerJoseph FarringtonChristiann H GainesSaad KhanTroy D WilcoxTyler A RoyMichael R LeonardoAshley A OlsonLeona H GagnonVivek M PhilipWilliam ValdarFernando Pardo-Manuel de VillenaJames D JentschRyan W LoganColleen A McClungDonita L RobinsonElissa J CheslerLisa M Tarantino

Published in: Psychopharmacology (2020)

These CC strains offer a complex polygenic model system to study underlying mechanisms of cocaine response. We propose that CC041/TauUnc and CC004/TauUnc will be useful for studying genetic and biological mechanisms underlying resistance or vulnerability to the stimulatory and reinforcing effects of cocaine.

Keyphrases

escherichia coli
spinal cord injury
climate change
genome wide
gene expression
copy number