Enhancement of HIFU thermal therapy in perfused tissue models using micron-sized FTAC-stabilized PFOB-core endovascular sonosensitizers.

Orane LortonPauline GuilleminRyan HolmanStéphane DesgrangesLaura GuiLindsey A CroweSylvain TerrazAntonio NastasiFrançois LazeyrasChristiane Contino-PépinRares Salomir

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2021)

The current PFOB-FTAC micro-droplet sonosensitizers provided a large and sustained enhancement of the HIFU thermal deposition at the focal area, suggesting solutions for less technological constraints, lower risk for the near-/far- field heating. We also report a suitable experimental model for other MRgHIFU studies.

Keyphrases

high intensity
single cell
case control
stem cells
mesenchymal stem cells