N-Heterocyclic Carbene-Catalyzed Annulation of α-Chloroaldehydes with γ-/δ-Amino-α,β-Unsaturated Ketones: Enantioselective Synthesis of Pyrrolidones and Piperidones.
Zhao-Fei ZhangChun-Lin ZhangZhi-Yong SongZhong-Hua GaoSong YePublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
The N-heterocyclic carbene-catalyzed [2+3] and [2+4] annulations of α-chloroaldehydes with γ-/δ-amino-α,β-unsaturated ketones were developed, giving the corresponding pyrrolidones and piperidones in good yields with exclusive trans-selectivities and excellent enantioselectivities.
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