Anemoside B4 ameliorates TNBS-induced colitis through S100A9/MAPK/NF-κB signaling pathway.

Yong ZhangZhengxia ZhaWenhua ShenDan LiNaixin KangZhong ChenYanli LiuGuoqiang XuQiong-Ming Xu

Published in: Chinese medicine (2021)

Our results demonstrate that anemoside B4 prevents TNBS-induced colitis by inhibiting the NF-κB signaling pathway through deactivating S100A9, suggesting that anemoside B4 is a promising therapeutic candidate for colitis.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
mouse model
oxidative stress
lps induced
cell proliferation
ulcerative colitis
toll like receptor
nuclear factor