Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma.

Ji-Lin ChenPei-Yi ChuChun-Teng HuangTzu-Ting HuangWan-Lun WangYu-Hsuan LeeYuan-Ya ChangMing-Shen DaiChung-Wai ShiauChun-Yu Liu

Published in: Molecular medicine (Cambridge, Mass.) (2022)

These data suggest that SHP-1 negatively regulates phosphorylation of Lyn, and targeting SHP-1/p-Lyn using SHP-1 agonist has therapeutic potential for treatment of DLBCL.

Keyphrases

diffuse large b cell lymphoma
epstein barr virus
electronic health record
big data
cancer therapy
protein kinase
machine learning
deep learning
replacement therapy