ATG9 raises the BAR for PI4P in autophagy.

Published in: The Journal of cell biology (2019)

ATG9 vesicles are crucial for autophagy, yet the role of ATG9 remains unclear. In this issue, Judith et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201901115) implicate the BAR protein Arfaptin2 in the loading of PI4-kinase IIIβ onto ATG9 vesicles for recruitment of ATG13 to the site of autophagosome biogenesis.

Keyphrases

cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell therapy
stem cells
amino acid
tyrosine kinase
small molecule
protein protein
protein kinase
binding protein