The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.
Thomas J LittlejohnsJo HollidayLorna M GibsonSteve GarrattNiels OesingmannFidel Alfaro-AlmagroJimmy D BellChris BoultwoodRory CollinsMegan C ConroyNicola CrabtreeNicola DohertyAlejandro F FrangiNicholas C HarveyPaul LeesonKarla L MillerStefan NeubauerSteffen Erhard PetersenJonathan SellorsSimon SheardStephen M SmithCathie L M SudlowPaul M MatthewsNaomi E AllenPublished in: Nature communications (2020)
UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
Keyphrases
- high resolution
- dual energy
- magnetic resonance imaging
- computed tomography
- electronic health record
- big data
- clinical trial
- optical coherence tomography
- gene expression
- multiple sclerosis
- current status
- magnetic resonance
- bone mineral density
- contrast enhanced
- data analysis
- blood brain barrier
- resting state
- white matter
- copy number
- subarachnoid hemorrhage
- contrast enhanced ultrasound