Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia.
Olukemi JaiyesimiSivaraman KuppuswamyGuangwei ZhangSonia BatanWenbo ZhiVijay C GantaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our data present that inhibition of maladaptive PFKFB3-driven glycolysis in HSS-ECs is necessary to promote the UGP2-uridine diphosphate-glucose axis that enhances ischemic angiogenesis and perfusion recovery in experimental PAD.
Keyphrases
- contrast enhanced
- endothelial cells
- electronic health record
- vascular endothelial growth factor
- blood glucose
- magnetic resonance imaging
- big data
- ischemia reperfusion injury
- metabolic syndrome
- cerebral ischemia
- oxidative stress
- computed tomography
- adipose tissue
- machine learning
- insulin resistance
- blood brain barrier
- subarachnoid hemorrhage
- brain injury
- data analysis