Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria.

Olusola AjibayeAkinniyi A OsuntokiEmmanuel O BalogunYetunde A OlukosiBamidele A IwalokunKolapo M OyebolaKenji HikosakaYoh-Ichi WatanabeGodwin U EbilomaKiyoshi KitaAlfred Amambua-Ngwa

Published in: Malaria journal (2020)

This study has revealed low level of genetic polymorphisms in PfRH5 antigen with B- and T-cell epitopes in intrinsically unstructured regions along the PfRH5 gene in Lagos, Nigeria. A broader investigation is however required in other parts of the country to support the possible inclusion of PfRH5 in a cross-protective multi-component vaccine.

Keyphrases

plasmodium falciparum
binding protein
genome wide
copy number
single cell
gene expression
dna methylation
genetic diversity
transcription factor
genome wide identification