Targeting Podoplanin for the Treatment of Osteosarcoma.

Ai TakemotoSatoshi TakagiTakao UkajiNobuhiko GyobuMamoru KakinoMiho TakamiAsami KobayashiMarie LebelTokuichi KawaguchiMinoru SugawaraKazue Tsuji-TakayamaKenji IchiharaYuki FunauchiKeisuke AeSeiichi MatsumotoYoshiya Sugiura Kengo TakeuchiTetsuo NodaRyohei Katayama Naoya Fujita

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Targeting PDPN with a neutralizing antibody against PDPN-CLEC-2 without antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity is a novel therapeutic strategy for PDPN-positive osteosarcoma.

Keyphrases

cancer therapy
stem cells
dengue virus
combination therapy
bone marrow
replacement therapy