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Why not add some SPARKL to your life (and death)!?

Jesse D GellesJerry Edward Chipuk
Published in: Molecular & cellular oncology (2019)
Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.
Keyphrases
  • cell death
  • cell cycle arrest
  • single cell
  • induced apoptosis
  • signaling pathway
  • rna seq
  • pi k akt
  • endoplasmic reticulum stress
  • type diabetes
  • metabolic syndrome
  • cell proliferation