Daidzein from Dietary Supplement to a Drug Candidate: An Evaluation of Potential.
Mohammed Ubaidnull SalauddinMd Andalib ShadaniS M KawishMohammed AlbrattyHafiz A MakeenHassan A AlhazmiAsim NajmiKhalid ZoghebiMaryam A HalawiAbuzer AliMd Shamsher AlamZeenat IqbalMohd Aamir MirzaPublished in: ACS omega (2023)
Daidzein (DDZ) is a well-known nutraceutical supplement belonging to the class of isoflavones. It is isolated from various sources such as alfalfa, soybean, and red clover. It demonstrates a broad array of pharmacological/beneficial properties such as cardiovascular exercise, cholesterol reduction, and anticancer, antifibrotic, and antidiabetic effects, which make it effective in treating a wide range of diseases. Its structure and operation are the same as those of human estrogens, which are important in preventing osteoporosis, cancer, and postmenopausal diseases. It is thus a promising candidate for development as a phytopharmaceutical. Addressing safety, efficacy, and physicochemical properties are the primary prerequisites. DDZ is already ingested every day in varying amounts, so there should not be a significant safety risk; however, each indication requires a different dose to be determined. Some clinical trials are already being conducted globally to confirm its safety, efficacy, and therapeutic potential. Furthermore, as a result of its therapeutic influence on health, in order to establish intellectual property, patents are utilized. In light of the vast potential of eugenol, this review presents a detailed data collection on DDZ to substantiate the claim to develop it in the therapeutic category.
Keyphrases
- clinical trial
- healthcare
- endothelial cells
- public health
- mental health
- human health
- high intensity
- postmenopausal women
- papillary thyroid
- emergency department
- drinking water
- high throughput
- squamous cell carcinoma
- big data
- young adults
- risk assessment
- mass spectrometry
- squamous cell
- open label
- resistance training
- climate change
- phase iii
- drug induced
- pulmonary fibrosis
- breast cancer risk