Diagnosis and Outcomes of Late-Onset Wilson's Disease: A National Registry-Based Study.
Christelle NillesMickael Alexandre ObadiaRodolphe SobeskyJérôme DumortierOlivier GuillaudChloé LaurencinCaroline MoreauClaire VanlemmensFabienne Ory-MagneVictor de LedinghenEdouard Bardou-JacquetFrederique FluchèreCorinne ColletNouzha Oussedik-DjebraniFrance WoimantAurélia PoujoisPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
In the FWDR, late-onset forms of WD affect 8% of patients, mostly with neurological presentations. Thirty percent of the neurological forms were atypical (isolated long-lasting symptoms, inconspicuous brain MRI, no KFR). With personalized treatment, prognosis was good. This study emphasized that WD should be suspected at any age and even in cases of atypical presentation. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- late onset
- early onset
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- magnetic resonance imaging
- cerebral ischemia
- prognostic factors
- peritoneal dialysis
- pulmonary embolism
- quality improvement
- contrast enhanced
- type diabetes
- multiple sclerosis
- systematic review
- computed tomography
- brain injury
- skeletal muscle
- insulin resistance
- blood brain barrier
- functional connectivity
- smoking cessation
- glycemic control