Chyme Reinfusion Restores the Regulatory Bile Salt-FGF19 Axis in Patients With Intestinal Failure.
Kiran V K KoelfatDenis PicotXinwei ChangMireille Desille-DugastHans M van EijkSander M J van KuijkMartin LenicekSabrina LayecMarie CarsinLaurence DussaulxEloi SeynhaeveFlorence TrivinLaurence LacazeRonan ThibaultFrank G SchaapSteven W M Olde DaminkPublished in: Hepatology (Baltimore, Md.) (2021)
CR in patients with IF-TDE restored bile salt-FGF19 signaling and improved gut-liver function. Beneficial effects of CR are partly mediated by recovery of the bile salt-FGF19 axis and subsequent homeostatic regulation of bile salt synthesis.
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