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Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier.

Shin-Ichi AkanumaMyeongrae HanYuka MurayamaYoshiyuki KuboKen-Ichi Hosoya
Published in: Pharmaceutical research (2022)
Our study showed the comprehensive outcomes of imipramine and paroxetine transport at the BBB, implying that molecular mechanism(s) distinct from previously reported transporters and transport systems are involved in the transport.
Keyphrases
  • blood brain barrier
  • cerebral ischemia
  • oxidative stress
  • metabolic syndrome
  • skeletal muscle
  • insulin resistance