Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis.

Camila NascimentoA T Di Lorenzo AlhoC Bazan Conceição AmaralR E P LeiteR NitriniW Jacob-FilhoC A PasqualucciS R K HokkanenSally HunterH KeageGábor G KovácsL T GrinbergC K Suemoto

Published in: Neuropathology and applied neurobiology (2017)

Different methodology to access TDP-43, and also differences in lifestyle and genetic factors across different populations could explain our results. Standardization of TDP-43 measurement, and future studies about the impact of genetic and lifestyle characteristics on the development of neurodegenerative diseases are needed.

Keyphrases

amyotrophic lateral sclerosis
physical activity
binding protein
metabolic syndrome
genome wide
cardiovascular disease
weight loss
copy number
risk factors
circulating tumor
cognitive decline
current status
single molecule
dna methylation
type diabetes
gene expression