Current status of MEK inhibitors in the treatment of plexiform neurofibromas.

Andrea M GrossEva DombiBrigitte C Widemann

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

Sustained efforts and collaborations have resulted in identification of MEK inhibitors as effective therapy for NF1 pNF. Future work work will be directed at prevention of pNF morbidity and deepening the reponse in symptomatic pNF.

Keyphrases

current status
pi k akt
signaling pathway
lps induced
oxidative stress
cell proliferation
immune response
quality improvement
inflammatory response
combination therapy
replacement therapy