The dynamic alteration of transcriptional regulation by crucial TFs during tumorigenesis of gastric cancer.
Beiqin YuWentao DaiLi PangQingqing SangFangyuan LiJunxian YuHaoran FengJianfang LiJunyi HouChao YanLiping SuZhenggang ZhuYuan-Yuan LiBing-Ya LiuPublished in: Molecular medicine (Cambridge, Mass.) (2022)
By combining differential networking information and molecular cell experiments verification, testable hypotheses on the regulation mechanisms of GC around the core TFs and their top ranked DRLs were generated. Since TCEAL2 and MBNL1 have been reported to be potential therapeutic targets in SCLC and breast cancer respectively, their translation values in GC are worthy of further investigation.