Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Chong ChenChao-Yue CuiJun-Jun YuQian HeXiao-Ting WuYu-Zhang HeZe-Hua CuiCang LiQiu-Lin JiaXiang-Guang ShenRuan-Yang SunXi-Ran WangMin-Ge WangTian TangYan ZhangXiao-Ping LiaoBarry N KreiswirthShi-Dan ZhouBin HuangHong DuJian SunLiang ChenYa-Hong LiuPublished in: Genome medicine (2020)
Four tet(X) variants were identified in this study, and they were widely distributed in multiple Acinetobacter spp. strains from various ecological niches across China. Our research also highlighted the crucial role of ISCR2 in mobilizing tet(X)-like genes between different Acinetobacter species and explored the evolutionary history of Tet(X)-like monooxygenases. Further studies are needed to evaluate the clinical impact of these mobile tigecycline resistance genes.
Keyphrases
- genetic diversity
- acinetobacter baumannii
- multidrug resistant
- drug resistant
- genome wide
- pseudomonas aeruginosa
- escherichia coli
- klebsiella pneumoniae
- copy number
- bioinformatics analysis
- dna methylation
- climate change
- genome wide identification
- gene expression
- case control
- cystic fibrosis
- transcription factor
- genome wide analysis