Host-directed anti-mycobacterial activity of colchicine, an anti-gout drug, via strengthened host innate resistance reinforced by the IL-1β/PGE 2 axis.

Kee Woong Kwon Lee-Han KimSoon Myung KangJu Mi LeeEunsol ChoiJiyun ParkJung Joo HongSung Jae Shin

Published in: British journal of pharmacology (2022)

The repurposing of colchicine against Mtb infection in this study highlights its unique function in macrophages upon Mtb infection and its novel potential use in treating TB as host-directed or adjunctive therapy.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
immune response
uric acid
emergency department
stem cells
metabolic syndrome
risk assessment
drug induced
bone marrow
smoking cessation